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KMID : 0369820080380010051
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Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 1 p.51 ~ p.55
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Enhanced Dissolution Rate of Metformin HCl via GR-type Tablet with PAA and HPMC
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Seok Seung-Hun
Choi Jong-Seo
Hwang Chang-Hwan
Kang Chin-Yang
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Abstract
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To develop a novel metformin HCl-loaded GR type tablet, various tablets were compressed with poly acrylic acid (PAA) and hydroxypropylmethyl cellulose (HPMC) using a wet granulation, and their physical properties such as swelling rate, hardness and dissolution were then investigated. Among the formulae tested in this study, the tablet prepared with PAA 971 and 974 as disintegrants showed fastest dissolution rate and swelling rate. Furthermore, the tablets prepared with PAA and HPMC improved the swelling rate, hardness and dissolution compared to those prepared with only HPMC. Our results suggested that the tablets prepared with PAA 971, 974 and HPMC might be a potential candidate for gastric retention type tablets.
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KEYWORD
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Metformin HCl, gastric retention, PAA (Poly acrlic acid) HPMC (Hydroxy propyl methyl cellulose)
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